Translating Metabolomics to Cardiovascular Biomarkers
نویسندگان
چکیده
منابع مشابه
Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease.
The genetic architecture underlying the heritability of cardiovascular disease is incompletely understood. Metabolomics is an emerging technology platform that has shown early success in identifying biomarkers and mechanisms of common chronic diseases. Integration of metabolomics, genetics, and other omics platforms in a systems biology approach holds potential for elucidating novel genetic mar...
متن کاملSerum Metabolomics Profiling to Identify Biomarkers for Unstable Angina
Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable. In the present research, to gain insight into candidate biomarkers, the author draws on 1H NMR-based serum metabolic pro...
متن کاملMetabolomics and cardiovascular biomarker discovery.
BACKGROUND Metabolomics, the systematic analysis of low molecular weight biochemical compounds in a biological specimen, has been increasingly applied to biomarker discovery. CONTENT Because no single analytical method can accommodate the chemical diversity of the entire metabolome, various methods such as nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) have been empl...
متن کاملApplication of NMR metabolomics to search for human disease biomarkers.
Since antiquity, humans have used body fluids like saliva, urine and sweat for the diagnosis of diseases. The amount, color and smell of body fluids are still used in many traditional medical practices to evaluate an illness and make a diagnosis. The development and application of analytical methods for the detailed analysis of body fluids has led to the discovery of numerous disease biomarkers...
متن کاملTranslating imaging biomarkers into clinical practice
Biomarkers are ‘objectively measured and evaluated indicators of normal biological processes, pathogenic processes or pharmacologic responses to a therapeutic intervention’ that identify increased or decreased risk of patient benefit or harm [1]. Imaging biomarkers (IB) are integral to cancer healthcare and research. In oncology, patient management relies heavily on using ordered categorical IB...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Progress in Cardiovascular Diseases
سال: 2012
ISSN: 0033-0620
DOI: 10.1016/j.pcad.2012.06.004